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Plenary Talk at Intl. Photodynamic Association meeting, June 7, 2001, Vancouver BC, Canada
Optical Measurements for Quality Control During Photodynamic Therapy
Paulo R. Bargo, Teresa Goodell RN, Rodger Sleven MD, George Kovall MD, Greg Blair MD,
Steven L. Jacques
Oregon Medical Laser Center, Providence St. Vincent Medical Center, Portland, OR, USA
https://omlc.org/pdt/IPA2001/index.html
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Table of Contents
abstract
1. The basic dosimetry of PDT
2. The PDT treatment window
3. The FDA prescription for PDT
4. Equation for Reactive Oxidizing Species (ROS) production
5. Equation for depth of treatment
6. Variable blood perfusion affects optical absorption
7. Variable blood perfusion affects optical penetration depth
8. Optical penetration depth versus % blood content
9. Paulo Bargo's white-light reflectance endoscopic probe
10. Typical raw white-light reflectance measurements using endoscopic probe
11. Normalizing tissue measurements by standard measurements
12. Analysis scheme
13. Component spectra used to match in vivo spectra
14. Typical in vivo measurements of normal and tumorous esophagus
15. Optical penetration depth
16. Raw fluorescence spectra
17. Fluorophore in a cup of coffee versus in a cup of milk: how optics affects observation of fluorescence
18. The math of fluorescence versus photosensitizer concentration
19. One patient example: fluorescence vs concentration for normal and tumor
Never completed (sorry):
Data: fluorescence versus photosensitizer concentration
Converting photosensitizer concentration and light into Photodynamic Dose
Histograms of Photodynamic Dose for different depths in tissue
Preliminary histograms of light and drug received during FDA prescription
Conclusion
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