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The PDT treatment window is shown in the figure.

There must be enough photosensitizing DRUG and activating LIGHT to achieve effective PDT treatment. A threshold dose is defined as:

LIGHT x DRUG = threshold dose

Too much drug may lead to "dark toxicity." Too much light can lead to photodestruction or "photobleaching" of the drug.

IN THE CLINIC, one doctor must be sure that there is sufficient DRUG in the tissue and sufficient light penetrating the tissue to the desired depth so as to enter the PDT treatment window.

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