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The clinical study required a catheter probe that could be passed through the working channel of an endoscope for in vivo measurements of the esophagus or bronchial wall.

An endoscopic probe was designed at OMLC using two optical fibers terminating at two 45-degree mirrors made of polished steel. The arrangement allows the probe to deliver and collect light at 45-degree. The distance between the delivery and collection ports was 2.5 mm. A white light source was delivered through one fiber and collected light by the second fiber was routed to an inexpensive Ocean Optics spectrometer (http://www.oceanoptics.com) which despite its low spectral resolution proved adequate for the broad reflectance spectra found in tissue.

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