@inproceedings{duncan10a, author = {Donald D. Duncan and David G. Fischer and Mehran Daneshbod and Scott A. Prahl}, title = {Tissue structural organization: measurement, interpretation, and modeling}, booktitle = {SPIE Proceedings on Dynamics and Fluctuations in Biomedical Photonics {VII}}, year = {2010}, editor = {Adam Wax and Vadim Backman}, pages = {}, volume = {7563}, abstract = {Analysis of the first and second order statistical properties of light is powerful means of establishing the properties of a medium with which the light has interacted. In turn, the first and second order statistical properties of the medium dictate the manner in which light interacts with the medium. The former is the inverse problem and the latter is the forward problem. Towards an understanding of the propagation of light through complex structures, such as biological tissue, one might choose to explore either the inverse or the forward problem. Fundamental to the problem, however, is a physical parametric model that relates the two halves; a model that allows prediction of the measured effect or prediction of the parameters based on measurements. This is the objective of our study. \\[3mm] As a means of characterizing the first and second order properties of tissue, we discuss measurements using differential interference contrast microscopy and a phase-stepping Mach-Zehnder interferometer. First and second order properties are characterized respectively in terms of scatter phase functions and spatial power spectral densities Results are shown for a number of representative tissue types. To explore the utility of such parametric tissue models, we report preliminary efforts at quantifying the effects of partial spatial coherence. These measurements are made on various biological media using a spatial light modulator within the Mach-Zehnder interferometer.}, }