Conference 3254A Monday-Wednesday 26-28 January 1998 Proceedings of SPIE Vol. 3254 Laser-Tissue Interaction IX Conference Chair: Steven L. Jacques, Oregon Medical Laser Ctr. Program Committee: Wei R. Chen, Univ. of Oklahoma; Robert P. Godwin, Los Alamos National Lab.; Tayyaba Hasan, Wellman Labs. of Photomedicine, Massachusetts General Hospital, and Harvard Medical School; E. Duco Jansen, Vanderbilt Univ.; Richard A. London, Lawrence Livermore National Lab.; Alexander A. Oraevsky, Rice Univ.; Scott A. Prahl, Oregon Medical Laser Ctr.; William P. Roach, Air Force Office of Scientific Research; Rudolf M. Verdaasdonk, Univ. Hospital Utrecht (Netherlands); Lihong Wang, Texas A&M Univ. Monday 26 January SESSION 1 Mon. 8:30 to 10:10 am Immunologic Mechanisms During PDT I Chair: Wei R. Chen, Oklahoma School of Science and Mathematics and Univ. of Oklahoma Cancer treatment by photodynamic therapy combined with NK cell line-based adoptive immunotherapy (Invited Paper), M. Korbelik, J. Sun, British Columbia Cancer Agency (Canada) [3254-01] Photodynamic therapy and cellular immune response (Invited Paper), G. L. Canti, Univ. di Milano (Italy); R. Cubeddu, P. Taroni, G. Valentini, Politecnico di Milano (Italy) [3254-02] Photodynamic therapy affects the expression of IL-6 and IL-10 in vivo (Invited Paper), S. O. Gollnick, D. A. Musser, B. W. Henderson, Roswell Park Cancer Institute [3254-03] Anti-tumor immune responses induced by photodynamic immunotherapy in rats, W. R. Chen, Oklahoma School of Science and Mathematics and Univ. of Oklahoma; K. Robinson, Oklahoma School of Science and Mathematics; R. L. Adams, Dean A. McGee Eye Institute and Univ. of Oklahoma; A. Singhal, Xytronyx Inc.; R. E. Nordquist, Wound Healing of Oklahoma, Inc. [3254-04] SESSION 2 Mon.10:40 am to Noon Immunologic Mechanisms During PDT II, Photochemical Mechanisms Chair: Tayyaba Hasan, Wellman Labs. of Photomedicine and Harvard Medical School Immune modulation using photosensitizers and light (Invited Paper), J. G. Levy, M. Obochi, D. W. Hunt, J. Tao, QLT PhotoTherapeutics Inc. (Canada) [3254-05] Morphological studies of metastatic mammary rat tumors after laser immunotherapy treatment, R. E. Nordquist, J. A. Nordquist, Wound Healing of Oklahoma, Inc.; W. R. Chen, Oklahoma School of Science and Mathematics and Univ. of Oklahoma [3254-06] Relief of vasospasm by intravascular ultraviolet irradiation, K. Nakai, M.D., Y. Morimoto, M.D., H. Ito, M.D., K. Kominami, M.D., H. Matsuo, M.D., T. Arai, M.D., M. Kikuchi, National Defense Medical College (Japan) [3254-07] Relative photoreactivity of the pigment inclusions of the retinal pigment epithelium, R. D. Glickman, DUniv of Texas Health Science center at San Antonio; A. E. Dontsov, M. A. Ostrovsky, Institute of Bio-Chemical Physics of the Russian Academy of Sciences, Moscow [3254-08] Lunch Break SESSION 3 Mon. 1:30 to 3:00 pm Photothermal Mechanisms Chair: Steven L. Jacques, Oregon Medical Laser Ctr. Theoretical model of structural alterations in laser-heated cartilage including effects of water evaporation and mass diffusion, E. N. Sobol, M. S. Kitai, A. P. Sviridov, Research Ctr. for Technological Lasers (Russia); T. E. Milner, B. Wong, Beckman Laser Institute and Medical Clinic [3254-09] Laser-induced heat diffusion limited tissue coagulation II: effect of random temperature nonuniformities on the form of a spherical and cylindrical necrosis domain, I. A. Lubashevsky, A. V. Priezzhev, Moscow State Univ. (Russia) [3254-10] Correlation of thermal and mechanical effects of the holmium laser for various clinical applications, R. M. Verdaasdonk, C. F. van Swol, M. C. Grimbergen, Univ. Hospital Utrecht (Netherlands) [3254-37] Accidental bilateral Q-switched neodymium laser exposure: treatment and recovery of visual function, BE Stuck, H Zwick, US Army Medical Research Detachment of the Walter Reed Army Institute of Research, Brooks AFB; DK Scales, Wilford Hall Medical Center; DJ Lund, US Army Medical Research Detachment of the Walter Reed Army Institute of Research, Brooks AFB. [3254-XX] SESSION 4 Mon. 3:30 to 4:50 pm Photoacoustic Mechanisms Chair: Richard A. London, Lawrence Livermore National Lab. Effects of stress waves on cells, H. Campbell, S. R. Visuri, L. B. Da Silva, Lawrence Livermore National Lab. [3254-13] Interferometric technique to measure shock-induced surface velocities in tissues for the determination of dynamic mechanical properties, U. S. Sathyam, P. M. Celliers, L. B. Da Silva, Lawrence Livermore National Lab. [3254-14] Generating subsurface acoustic waves in indocyanine green dyed gel using a Q-switched laser, J. A. Viator, Oregon Graduate Institute; S. A. Prahl, S. L. Jacques, Oregon Medical Laser Ctr. [3254-15] Computer simulations of the effect of pulse length on laser-tattoo interaction, D. Ho, R. A. London, M. E. Glinsky, D. A. Young, Lawrence Livermore National Lab. [3254-16] Internal photomechanical fracture of spatially limited absorbers irradiated by short laser pulses, G. Paltauf and H.Schmidt-Kloiber, Karl-Franzens-University Graz (Austria) [3254-67] Tuesday 27 January SESSION 5 Tues. 8:30 to 10:10 am Ocular I: Pulsed Laser Effects on Tissues Chair: William P. Roach, Air Force Office of Scientific Research Windows of Opportunity: Applying Ultrashort Laser Pulses for Selective Tissue Effects, C. A. Toth, M.D., Duke Univ.; C. Cain, G. Noojin, TASC, Inc.; W. P. Roach, Air Force Office of Sponsored Research; Benjamin Rockwell, Armstrong Laboratory, Brooks AFB. [3254-17] Visible lesion threshold dependence on retinal spot size for near infrared laser pulses in the primate eye, C. P. Cain, G. D. Noojin, D. J. Stolarski, The Analytical Sciences Corp.; R. E. Amnotte, Air Force Research Lab.; V. Caruthers, The Analytical Sciences Corp.; B. A. Rockwell, Air Force Research Lab. [3254-18] Effect of laser pulse width on artifical retina damage, D. J. Payne, R. A. Hopkins, Jr., Air Force Research Lab.; G. D. Noojin, The Analytical Sciences Corp.; B. Eilert, B. A. Rockwell, Air Force Research Lab. [3254-19] Microscopic simulation of short pulse laser damage of melanin particles, L. V. Zhigilei, B. J. Garrison, The Pennsylvania State Univ. [3254-20] SESSION 6 Tues.10:40 am to 12:20 pm Ocular II: Mechanisms of Laser Effects Chair: Bernard S. Gerstman, Florida International Univ. Granular retinal damage model with photothermal and photomechanical effects, P. K. Kennedy, J. J. Druessel, Air Force Research Lab.; B. S. Gerstman, Florida International Univ.; C. R. Thompson, Lockheed Martin; B. A. Rockwell, Air Force Research Lab. [3254-21] Pressure generation in melanosomes by subnanosecond laser pulses, J. Sun, B. S. Gerstman, Florida International Univ. [3254-22] Self-focusing of ultrashort laser pulses in the presence of small time dispersion and nonparaxiality, G. Fibich, Tel-Aviv Univ. (Israel); G. C. Papanicolaou, Stanford Univ. [3254-23] Energy balance of optical breakdown in water, A. Vogel, K. Nahen, J. Noack, S. Busch, Medizinisches Laserzentrum Luebeck (FRG); U. Parlitz, Univ. Goettingen (FRG); R. Birngruber, Medizinisches Laserzentrum Luebeck (FRG) [3254-24] Acoustic energy dissipation after laser-induced breakdown, A. Vogel, J. Noack, Medizinisches Laserzentrum Luebeck (FRG) [3254-25] Lunch/Exhibit Break SESSION 7 Tues. 1:30 to 3:00 pm Ablation I Chair: E. Duco Jansen, Vanderbilt Univ. Microsecond-scale nonlinear mechanisms during pulsed Ho:YAG irradiation of nonscattering tissue using thermal microscopy, T. Pfefer, K. Chan, D. X. Hammer, A. J. Welch, Univ. of Texas/Austin; M. Ith, M. Frenz, Univ. Berne (Switzerland); E. Jansen, Vanderbilt Univ. [3254-26] Therapeutic ultrashort pulsed laser tissue ablation, B. Kim, L. B. Da Silva, M. D. Feit, R. A. London, M. D. Perry, A. M. Rubenchik, B. C. Stuart, Lawrence Livermore National Lab. [3254-27] Synthetic thrombus model for in vitro studies of laser thrombolysis, R. E. Hermes, K. Trajkovska, Los Alamos National Lab. [3254-28] Acoustic spectroscopy of Er:YAG laser ablation of skin: first results, K. Nahen, A. Vogel, Medizinisches Laserzentrum Luebeck (FRG) [3254-29] SESSION 8 Tues. 3:30 to 4:50 pm Ablation II Chair: Rudolf M. Verdaasdonk, Univ. Hospital Utrecht (Netherlands) Hard tissue simulations using the LATIS code, D. Bailey, R. A. London, W. E. Alley, Lawrence Livermore National Lab. [3254-31] Fabrication of biosynthetic vascular protheses by 193 nm excimer laser radiation, W. Husinsky, C. Csek, Technische Univ. Wien (Austria); M. Grabenwoeger, F. Fitzal, E. Wolner, Univ. Wien (Austria) [3254-32] Characterization of tissue processing with a continuous wave Tm:YAG laser at 2.06 m wavelength, H. Lubatschowski, Laser Zentrum Hannover e.V. (FRG); M. Fiebig, P. Fuhrberg, H. O. Teichmann, LISA Laser Products OHG (FRG); H. Welling, Laser Zentrum Hannover e.V. (FRG) [3254-33] Wednesday 28 January SESSION 9 Wed. 8:30 to 10:10 am Bubbles Chair: Robert P. Godwin, Los Alamos National Lab. Scaling laws for laser-produced bubbles in soft tissue, R. A. London, D. S. Bailey, P. A. Amendt, S. R. Visuri, Lawrence Livermore National Lab. [3254-34] Simulations of waves and cavitation bubbles produced in water by picosecond and nanosecond laser pulses, R. J. Scammon, E. J. Chapyak, R. P. Godwin, Los Alamos National Lab.; A. Vogel, Medizinisches Laserzentrum Luebeck (FRG) [3254-35] Fluorescence-based temperature measurements in laser-induced vapor bubbles, K. Chan, T. Pfefer, D. X. Hammer, Univ. of Texas/Austin; E. Jansen, Vanderbilt Univ.; M. Frenz, Univ. Berne (Switzerland); A. J. Welch, Univ. of Texas/Austin [3254-36] Two-dimensional vapor bubble simulations for medical applications, P. Amendt, D.S. Bailey, R.A. London, D. Maitland, Lawrence Livermore Natl. Lab.; M.Strauss, Nuclear Research Ctr. (Israel) [3254-XX] Bubble dynamics using a long pulse Nd:YAG laser, J. A. Viator, S. A. Prahl, Oregon Medical Laser Ctr. [3254-38] SESSION 10 Wed.10:40 am to Noon Optoacoustic Imaging and Sensing Chair: Alexander A. Oraevsky, Rice Univ. Axial resolution of laser optoacoustic imaging: influence of acoustic diffraction and absorption, R. O. Esenaliev, H. Alma, F. K. Tittel, A. A. Oraevsky, Rice Univ. [3254-39] Detection of buried objects using surface fluctuations from acoustic waves as measured with a differential laser Doppler vibrometer, S. G. Hanson, Riso National Lab. (Denmark); S. L. Jacques, Oregon Medical Laser Ctr.; P. E. Andersen, L. R. Lindvold, Riso National Lab. (Denmark) [3254-40] Comparison with transient measurements of infrared radiation and stress wave for the practical ablation monitoring during photorefractive keratectomy, M. Yoshikawa, T. Arai, M.D., M. Kikuchi, National Defense Medical College (Japan); H. Nakano, S. Kawauchi, M. Obara, Keio Univ. (Japan) [3254-41] Recent development in photoacoustic image reconstruction, (Invited Paper), P. Liu, Indiana Univ. School of Medicine [3254-42] Lunch/Exhibit Break SESSION 11 Wed. 1:30 to 3:00 pm Optics I Chair: Scott A. Prahl, Oregon Medical Laser Ctr. Measurement of tissue optical properties and modeling of optimal light delivery for tumor treatment, L. Wang, Texas A&M Univ.; W. R. Chen, Oklahoma School of Science and Mathematics and Univ. of Oklahoma; R. E. Nordquist, Dean A. McGee Eye Institute and Univ. of Oklahoma [3254-43] Laser-induced straining of a biologic material analyzed using a polariscopic imaging technique, J. T. Walsh, Jr., Northwestern Univ.; G. P. Delacretaz, D. Beghuin, Ecole Polytechnique Federale de Lausanne (Switzerland) [3254-44] Novel algorithm to determine absorption and scattering coefficient from time-resolved measurement, R. K. Wang, Y. A. Wickramasinghe, P. Rolfe, Keele Univ. (UK) [3254-45] Sized fiber array spectroscopy, S. A. Prahl, S. L. Jacques, Oregon Medical Laser Ctr. [3254-46] SESSION 12 Wed. 3:30 to 4:50 pm Optics II Chair: Lihong Wang, Texas A&M Univ. Dependence of light transmission through human skin on incident beam diameter at different wavelengths, Z. Zhao, P. W. Fairchild, ThermoLase Corp. [3254-47] System of measurement of the transmission spectrum of "in vitro" corneas for eye banks, J. de Meneses Bispo, L. Ventura, C. R. de Carvalho, Jr., S. J. de Faria e Sousa, C. Chiaradia, Univ. de Sao Paulo (Brazil) [3254-48] Changes in the optical properties of laser-coagulated and thermally coagulated bovine myocardium, A. N. Yaroslavsky, A. Terenji, S. Willmann, I. V. Yaroslavsky, Heinrich-Heine-Univ. (FRG); H. Schwarzmaier, German National Research Ctr. for Information Technology (FRG) [3254-49] Pressure effects on soft tissues monitored by changes in tissue optical properties, H. Shangguan, S. A. Prahl, S. L. Jacques, K. W. Gregory, M.D., Oregon Medical Laser Ctr. [3254-50]