@article{moffitt04a,
  author = {Theodore P. Moffitt and Scott A. Prahl},
  title = {Sensitivity of a Reflection Mode Optical Fiber System to the Orientation of Tissue Fiber within In Vitro Tissues},
  journal = {Proceedings of the Oregon Academy of Science},
  volume = {40},
  pages = {52},
  year = {2004 abstract only},
  abstract = {Evaluation of tissue fiber architecture is important for optimally engineering tissues. We present a non-destructive reflection mode optical fiber system that is sensitive to the orientation of tissue fibers within the same plane as the surface of the tissue. Our system uses a single 1000 micron diameter optical fiber that is bifurcated to separate emitted from collected light. The face of the 1000 micron fiber is polished at a 65 degree angle to the central axis of the optical fiber for two reasons: to eliminate effects of specular reflections from the tissue/fiber-face interface and to give directionality to the light emitted into the tissue. We present results using this fiber system to measure 15 micron thick cross-sections of in vitro porcine heart muscle and full thickness ($\sim$2\,mm) digested aortic elastin rotated 360 degrees in 15 degree increments. These results are correlated to concurrent transmission measurements of small angle light scattering (SALS) recorded using a CCD camera to conclusively determine the orientation of the fibrous architecture of each tissue type. We show a 14\% peak-to-peak change in reflection signal on the heart muscle tissue and a 6\% peak-to-peak change on the digested elastin.},
}